The Anti-Defamation League, also known as the ADL, is a special human relations agency founded in 1913 by B'nai B'rith in the United States, the oldest continually operating Jewish Service Organization in the world. A recognized leader in its field, the ADL is dedicated in purpose and program to translating the U.S.’s heritage of democratic ideals into a way of life for all Americans.The declared mission of the ADL is "to stop, by appeals to reason and conscience and, if necessary, by appeals to law, the defamation of the Jewish people. Its expressed purpose is to secure justice and fair treatment to all citizens alike and to put an end forever to unjust and unfair discrimination against and ridicule of any sect or body of citizens."

The San Diego Regional Office of the ADL has been serving the San Diego and Imperial Counties since 1978. Its declared aim is to keep the community safe through Education, Protection, and Investigation. It promotes educational programs for high school students, young professionals, Catholics educators, local and federal law enforcement, local Jewish institutions, and the general community at large, while addressing and resolving discrimination complaints, acts of Antisemitism, hate crimes, and civil rights violations.